ABSTRACT
Chronic intermittent hypoxia ( CIH ) caused by ob-structive sleep apnea hypopnea syndrome( OSAHS) is an impor-tant factor causing or aggravating many kinds of cardiovascular and cerebrovascular diseases. Establishing a rational animal model for intermittent hypoxia is an essential method to study the CIH related cardiovascular diseases. Recently, researchers have tended to simulate intermittent hypoxia condition by controlling the oxygen concentration of the environmental air around the ani-mals. In the paper, we summarize and compare the methods of making intermittent hypoxia animal model in recent literature, from aspects of experimental animals, gas control apparatus, gas species and concentration, intermittent hypoxia treatment time, and anoxic cycle mode.
ABSTRACT
To analyze the relationships among syndrome, therapeutic method and Chinese herbal medicine in patients with coronary artery disease (CAD).
ABSTRACT
According to the basic theory of traditional Chinese medicine (TCM), the pathogenetic factors such as platelet activation, adhesion, congregation and thrombosis fall into the category of blood stasis, while the pathological changes such as tissue necrosis, oxidative stress injury and inflammation, etc, are far beyond the etiological category of blood stasis. The toxin or the combination and transformation of toxin and blood stasis of TCM are involved in the pathogenesis of thrombotic cerebro-cardiovascular diseases. It is significant to recognize and stress the combination and transformation of toxin and stasis in pathogenicity so as to enrich TCM etiology and improve TCM clinical efficacy in the treatment of cerebro-cardiovascular and thrombotic diseases.
ABSTRACT
The traditional Chinese medicines come from natural and include many kinds of active ingredients.The clinical and experimental studies indicate that some traditional Chinese medicines(including the compound and the monomer)may regulate the lipid on multi-targets in vivo,which has certain value in only research and application.Present clinical researches on traditional Chinese medicines for lipid-regulation are limited in only regulating biochemistry level,small samples,poor repeatability,short of multi-central large-sample random-control experiments and absence of long term follow-up on cardiovascular and cerebrovascular adverse events.We should take the advantage of traditional Chinese medicine superiority in lipid-regulating process by scientific researches.